from the Western Ghats, India, Preliminary screening of potential flavonoid-subclasses in Myristica fragrans and Cordyline terminalis by LC-ESI-MS, Aromatic compounds from Endocomia macrocoma, Myristigranol, a new diarylpropane derivative from the wood of Myristica fragrans, Assessment of chemically characterised Myristica fragrans essential oil against fungi contaminating stored scented rice and its mode of action as novel aflatoxin inhibitor, Phytochemical investigation on Myristica fragrans stem bark. However, results obtained from most studies are often inconsistent due to the variability of utilized samples, lack of standardized nutmeg products or insufficient amounts of pure compounds for comprehensive follow-up investigation. chemical composition and antioxidant activity of the glycosidically bound volatiles in nutmeg have not been reported to date. FEMA No. Scientists from various disciplines are now directing their research towards investigat-ing the effects of M. fragrans on human health. To characterize the neuropharmacological effects of different nutmeg extracts, administered orally. The results showed that nutmeg oil can be developed as potent anti-cancer and antioxidant drugs. Regression analysis yielded LD(50/30 )as 6.83 Gy and 8.89 Gy for irradiated only and (MF + radiation) groups, respectively. Nutmeg at high doses is considered a cheap substitute to several drugs of abuse. Natural Product Communications, 10(8): 1399-1402. NIH INTRODUCTION Myristica fragrans is commonly known as “nutmeg”, it produces two spices: mace and nutmeg. 1973. Screening of potential flavonoid-subclasses was done by LC-ESI-MS, whose data were interpreted using database of Lipid Metabolites and Pathways Strategy Consortium. 2018 Oct 30;23(11):2817. doi: 10.3390/molecules23112817. Nutmeg (Myristica fragrans Houtt. The species is dioecious, i.e. Studies on dental caries prevention by traditional medicines. Nutmeg is the The chemical constituents of the extracts were quantified via high performance liquid chromatography (HPLC). Material and Methods: The essential oil was obtained from nutmeg and cardamom seeds through hydrodistillation method. Myristica fragrans oil. Here, preliminary phytochemical screening and total flavonoid content in extracts of seeds of Myristica fragrans and leaves of Cordyline terminalis have been investigated. There were obvious differences between the FTIR spectrums of above-mentioned plants. 2019 Mar 18;24(6):1062. doi: 10.3390/molecules24061062. RESULTS: Thirty‐eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. Aiba CJ, Correa CRG, Gottlieb OR. Nutmeg (Myristica fragrans Houtt. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Financial support from CSIR.  |  Myristica fragrans Houtt., the source of very important spice ‘nutmeg’ used world over is native to India, Indonesia, Sri Lanka, South Africa and Southeast Asia. ... Chemical composition – Monoterpene hydrocarbons represent more than 80% of α-pinene of the total composition, β-pinene, α and β-terpinene, myrcene, camphene, limonene and sabinene, α and β-phellandrene, 3-carene, terpineol, α-tujene, p-cymene and 1, 4-mentadiene. Although extensive literature exists on antioxidant properties of medicinal plants, very few studies have focused on their polyphenolic composition. Antimicrobial activity of, Tommy I, Shiming L, Knut L. 1998. All figure content in this area was uploaded by Mangalam Nair, All content in this area was uploaded by Mangalam Nair on Aug 24, 2016, Full Terms & Conditions of access and use can be found at, http://www.tandfonline.com/action/journalInformation?journalCode=gnpl20, ISSN: 1478-6419 (Print) 1478-6427 (Online) Journal homepage: http://www.tandfonline.com/loi/gnpl20, Chemical constituents from Myristica fragr, K. Sajin Francis, Eringathodi Suresh & Mangalam S. Nair, constituents from Myristica fragrans fruit, Natur, Chemical Sciences & Technology Division, CSIR-National Institute for Interdisciplinary Science and. The proximate analysis of nutmeg and mace, unlike in most earlier reports, has been carried out using the raw spices. : 3-(3, 4, 5-trimethoxyphenyl)-2-(E)-propen-1-ol (1), 3-(3-methoxy-4, 5-methylenedioxyphenyl)-2-(E)-propen-1-ol (2), 2, 3-dihydro-7-methoxy-2-(3, 4-dimethoxyphenyl)-3-methyl-5-(1-(E)-propenyl)benzofuran (3), fragransol-C (4), fragransol-D (5), 2, 3-dimethyl-1, 4-bis-(3, 4-methylenedioxyphenyl)butan-1-ol (6), myristicanol-A (7) and myristicanol-B (8). Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia. From this extract, eight new neolignans, maceneolignans A-H (1-8), were isolated, and their stereostructures were elucidated from their spectroscopic values and chemical properties. It is a well-known aromatic perennial plant with a characteristic scent that possesses multiple medicinal applications, being used to treat stomach ulcers, indigestion, liver disorders, and as emmenagogue, nervine, diuretic, diaphoretic, and aphrodisiac. Compounds 4, 5, 7 and 8 are new neolignans which may be formed by coupling of cinnamyl alcohol and propenylbenzene unis. Ashour ML, El-Readi M, Youns M, Mulyaningsih S, Sporer F, Efferth T, Wink M. J Pharm Pharmacol. Seed extracts from Myristica fragrans (Nutmeg) and ... and metal‐induced oxidative damage in penile homogenate in vitro. Display Name: Myristica fragrans, ext. Gas chromatography-mass spectrometry analysis of essential oil showed the presence of 38 components representing about 99.6% of the total weight. From nutmeg, a seed of Myristica fragrans Houtt., were isolated thirteen phenylpropanoids. Material and Methods: The essential oil was obtained from nutmeg and cardamom seeds through hydrodistillation method. Medically reviewed by Drugs.com. Chemical Composition, Antimicrobial and In Vitro Antioxidant Properties of Monarda citriodora var. China. doi: 10.1111/j.1750-3841.2012.02618.x. 2793. Methanolic (ME), dichloromethane (DE), and hexane (HE) extracts were obtained from a chromatographically fingerprinted batch of nutmeg. © 2008-2020 ResearchGate GmbH. Our nutmeg oil is extracted from Myristica fragrans (also known as Myristica officinalis, M. oromata and Nux moschata) of the Myristicaceae family and is also known as jatiphala. Elemicin, galbacin, veraguensin and two new neolignans, surinamensin and virolin, were isolated and characterized from the leaves of Virola surinamensis. Myristica fragrans is native to the exotic Spice Islands or Maluku of Indonesia, though it now also grown in India, Malaysia, Sri Lanka, Taiwan, China, and the Caribbean region, amongst other countries. The most common targets include GIT, CNS, oxidative stress and inflammation. The chemical composition of nutmeg and mace of Myristica fragrans collected from Tellicherry and Kannur areas (North Kerala) was studied. Results: MF inhibited seizures induced by MES, PTZ, and Li-Pilo.  |  Group-1 was normal control and 2-5 groups were fed with cafeteria diet for 15 weeks to induce obesity. Thus, the structure of the compound was, (Merck, Bangalore, India) and CC on Si gel 100, with tetramethylsilane as internal standard. All rights reserved. Mass spectra were recorded under ESI/HR-MS at 61,800 resolution using Thermo Scientific, exactive mass spectrometer (Thermo Fischer Scientific, Brem, Voucher specimen (TBGRI-60679) has been deposited in a herbari, Tropical Botanical Garden and Research Institute, Palode, Trivandr. 1973. Phytochemistry. Acta Chem Scand. The EO was extracted by hydrodistillation and analysed by GC-MS. Access scientific knowledge from anywhere. A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated from Myristica fragrans for the first time. Copyright © 2011 Society of Chemical Industry. Many studies on the biological activities of nutmeg continue to appear in the literature. The availability of purified compounds will also allow the development of specific, accurate, and sensitive analytical procedures for pharmacokinetic studies and for quality control of nutmeg products. )-prop-1-enyl)-2-(3,4,5-tri methoxy phenyl)-2,3-dihydrobenzofuran, licarin B, http://dx.doi.org/10.1080/14786419.2014.934236, ). This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of M. fragrans. Myristigranol, a new diarylpropane derivative, was isolated from the methanol extract of Myristica fragrans wood along with one diarylpropanoid and three stilbenoids. 2009 Aug;61(8):1079-87. doi: 10.1211/jpp/61.08.0012. seed essential oil on the locomotor activity of mice in a wheel cage. The ethanol-extracted essential oil of M. fragrans showed bioactivity against adult female whiteflies, with different concentrations exerting significant activities for different durations. The mengkudu oil exhibited IC₅₀ values of 91.46 and 78.15 µg mL⁻¹ for HCT-116 and MCF-7, respectively. Conclusion: PDF. The ethyl acetate soluble part (19 g) was subjected to CC on silica gel (100, Fraction 5 was submitted to CC on silica gel by eluting with hexane, crystallisation in hexane afforded mixture of stigmasterol and, when subjected to CC on neutral alumina, afforded accuminatin, guaiacin (10 mg). di Scienze Chimiche, Univ. East indian nutmeg oil. Nutmeg is the The wood of Virola multinervia Ducke (Myristicaceae) contains sitosterol, stigmasterol and two novel diarylpropanoids virolane [1-(2-hydroxy-4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-propane] and virolanol [2-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-propane]. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of M. fragrans. The. Central Salt and Marine Chemicals Research Institute, National Institute for Interdisciplinary Science and Technology, Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli, Compositional variation in the leaf, mace, kernel, and seed essential oil of nutmeg (Myristica fragrans Houtt.) When the oil is made from the husks it produces mace. growing in the Western Ghats, India was investigated for the first time. Volatiles Profiling, Allelopathic Activity, and Antioxidant Potentiality of, A Design of Experiment Approach for Ionic Liquid-Based Extraction of Toxic Components-Minimized Essential Oil from, Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (. Clipboard, Search History, and several other advanced features are temporarily unavailable. CAS Number: 84082-68-8 Molecular formula: Unspecified (UVCB) Nutmeg Oil is the essential oil obtained from ground nutmeg. Phytochemistry. Scientific Name(s): Myristica fragrans Houtt.Common Name(s): Nutmeg, mace, සාදික්කා වසාවාසි magic, muscdier, nux moschata, myristica oil, muskatbaum Use Nutmeg and mace, widely accepted as flavoring agents, have been used in higher doses for their aphrodisiac and psychoactive properties. The chemical constituents in Myristica fragrans seeds were ana-lyzed using proximate analysis, atomic absorption spectroscopic (AAS), phytochemical and gas chromatographic-mass spectro-metric (GC-MS) methods. The chemical composition of nutmeg and cardamom essential oil … Nutmeg is the seed or ground spice of several species of the genus Myristica. Myristica oil. Phytochem Rev. This also was used to pinpoint instances where MS-MS spectra contained contributions from more than one structural isomer. ), belonging to the family Myristicaceae, is a spice seed from the fruit of a tropical evergreen tree. Chemical constituents Nutmeg principally contains volatile oil (5 to 15 percent) and fat (30 to 40 percent). Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Nutmeg, Myristica frangrans, is a very important tree spice, having both industrial and medicinal applications. ARTICLE HISTORY. Myristica fragrans is a fragrant tree, known for its commercial spicy products, namely, the nutmeg, mace, and essential oil, which are predominantly used in flavor, fragrance, and pharmaceutical industries. The minimum inhibitory and minimum aflatoxin inhibitory concentrations of MFEO were 2.75 and 1.5 mg/ml, respectively. The following constituents were isolated for the first time from the aril of Myristica fragrans HOUTT. - Biological Ef fects of Myristica fragrans 23. geraniol, terpineol, together 5 to 15%) and phenylpropanoids (myristicin, elemicin, safrole, eugenol. and Myristica malabarica Lamk. 2015. Results: X. Antibacterial action of phenolic components from mace against, Hattori M, Yang XW, Shu YZ, Kakiuchi N, Tezuka Y, Kikuchi T, Namba T. 1988. Nutmeg oleoresin. This is the first report on the bioassay-guided characterization of constituents in nutmeg pericarp. Structures of isolated compounds, 1.19 (d), 1.89 (dd)], four methoxy groups [, 3.82 (s), 3.85 (6H, s), 3.90 (s)], a hydroxyl group, O], five aromatic protons and two olefinic protons [, integrating for one proton and a doublet of quartet at, C NMR and DEPT spectra showed the presence o, six methyl, nine methine and seven quaternary carb, 55.9 and 60.8 could be attributed to methoxy groups. This is the first report on MFEO as aflatoxin suppressor. Chemical Composition and Antioxidant Activity of Essential Oil and Oleoresins of Nutmeg (Myristica fragransHoutt.) Cytotoxicity evaluation of the new compounds against five human tumor lines showed no inhibitory effects. Piaru SP, Mahmud R, Abdul Majid AM, Mahmoud Nassar ZD. The chemical composition of nutmeg and cardamom essential oil was analyzed by GC-MS. Download Free PDF. Antioxidant lignans from Machilus thunbergii, -injured primary cultures of rat hepatocytes. Nutmeg oil is sharp, spicy and rather musky in aroma. Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Create a free account to download. To address the consistency and supply issue we utilized available technology to develop a reproducible procedure for preparation of specific extracts and isolation of the major phenolic constituents present in nutmeg kernel. Myristica fragrans seeds Rancy Ann Thomas, S Krishnakumari Abstract The curative effects of some plants for curing various human diseases could be as a result of the presence of bioactive constituents in them. Among them, seven compounds have been hitherto unknown. fruits were collected in January 2013, from Ernakulam in Kerala State. 55:589, Choo LC, Wong SM, Liew KY. 1999. CID 6616 (Camphene) CID 6850748 ( (2R,4R)-2-Methyl-1-methylidene-4-propan-2-ylcyclohexane) Date s. Modify. The hexane extract exhibited significant anti-conjugant activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult human dermal fibroblast cells. The major constituents of kernel and seed were sabi-nene, a-pinene, b-pinene, and D-limonene. is a large, leafy evergreen plant originating from Moluccas (the Spice Islands) and now cultivated in the West Indies. In this study, one new compound, a dehydrodiphenylpropanoid derivative of myristicin, was identified. Myristica fragrans (f. Myristicaceae) seeds are better known as a spice, but their chemical compounds may have a pharmacological effect. Intensity data for all the four crystals were collected usin, WI, USA) equipped with CCD area detector at 293, reduction were processed with SAINT software. The MFEO caused reduction in cellular methylglyoxal content, the aflatoxin inducer. are two well known tropical medicinal plants and widely used for the cure and management of many diseases and ailments. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) J Sci Food Agric. 2000. Nut and mace are commercially important spice products. 1978. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. Furthermore, the X-ray crystal structure of odoratisol A is reported in this paper for the first time. Keywords: nutmeg's oleoresin, heating, chemical compositions, antifungal properties. Nutmeg has been, ) has been found to have anti tuberculosis activity, ). It is clearly evident from the literature review that M. fragrans deserves more attention by scientific community and public health specialists to explore its full range of benefits in the welfare of the society. Seeds of M. fragrans were powdered and extracted with chloroform to obtain trimyristin, which on saponification yielded myristic acid. 2001. Myristica fragrans is an evergreen tree, usually 5–15 m (16–49 ft) tall, but occasionally reaching 20 m (66 ft) or even 30 m (98 ft) on Tidore.The alternately arranged leaves are dark green, 5–15 cm (2.0–5.9 in) long by 2–7 cm (0.8–2.8 in) wide with petioles about 1 cm (0.4 in) long. An empirical, to the collected reflections with SADABS. Results showed the percentage prox-imate composition of M. fragrans seeds as: crude ash < … Aril and kernel of the fruit of these plants are used in several ayurvedic preparations. The dose reduction. Supplementary material relating to this article is available online. The free radical scavenging activity of nutmeg … The major constituents of leaf, mace, kernel and seed of nutmeg can be utilised in the food, perfumery, aroma and pharmaceutical industries. Nutmeg, Myristica fragrans, is known for its culinary and medicinal values. The essential oil (EO) from leaf, mace, kernel, and seed of Myristica fragrans Houtt. 2003. Apart from these two, previously known steroids, other lignans and neolignans were isolated from the fruit pericarp of M. fragrans. Biological effects of, Sonavane GS, Sarveiya VP, Kasture VS, Kasture SB. To the best of our knowledge, this is the first report on the isolation and identification of, . Indian materia medica. Myristica fragrans Houtt. RESULTS: Thirty‐eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. Piaru SP, Mahmud R, Abdul Majid AM, Ismail S, Man CN. Their structures were elucidated by spectroscopic analysis. The nutmeg pericarp, abundant during the production of the seed, is also used in food and beverage preparations. BACKGROUND: In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. 2007. It is also a commercial source of an essential oil and nutmeg butter. 2009. Myristica fragrans is an evergreen tree, usually 5–15 m (16–49 ft) tall, but occasionally reaching 20 m (66 ft) or even 30 m (98 ft) on Tidore.The alternately arranged leaves are dark green, 5–15 cm (2.0–5.9 in) long by 2–7 cm (0.8–2.8 in) wide with petioles about 1 cm (0.4 in) long. GC profiles of the oils compared very well with reports in Ii terature. [23] Utomo, J. dan M. Cisilia. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. A significant decrease in core body temperature was observed with HE at 100 mg/kg, while higher doses caused significant increases in hot plate latency. Main results: GC-MS analyzes shows that γ-terpinene (19.16%), (-)-terpinen-4-ol (14.08%), α-pinene (6.75%), myristicin (6.18%), β-pinene (4.85%), sylvestrene (4.72%), elemicin (4.68%) and safrole (4.17%) identified in. Active, expires 2033-12-08 Application number US14/036,097 Other versions Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia. and Myristica malabarica Lamk. A well-defined and reproducible sequence of extraction, fractionation and chromatographic purification was adopted and was guided by HPLC fingerprinting. Conclusion: MF has complex actions on the central nervous system. Being one of the popular spices in the culinary sector, the plant products are traditionally used in folk medicines for treating various human ailments. radiation on a Bruker SMART APEX diffractometer (Bruker AXS, has been deposited with the Cambridge Crystal, are reported from this plant for the first time. Groups of compounds with particular structural units were characterized by scans of all precursor ions which yield mass-selected fragment ions. The chemical constituents of M. fragrans have been investigated for hypolipidaemic and hypocholesterolemic effects, antimicrobial, antidepressant, aphrodi-siac, memory enhancing, antioxidant and hepatoprotective properties. Pure isolates 1−5 inhibited LPO by 70−99% and 3−12 inhibited COX-1 and -2 enzymes by 37−49%. on this page. Oil properties ... Chemical composition. The nutmeg sample is analyzed directly; no extraction, derivatization, or other sample preparation is necessary. 2012 Apr;5(4):294-8. doi: 10.1016/S1995-7645(12)60042-X. Also, α-terpinyl acetate (34.55%), eucalyptol (24.91%), (-)-terpinen-4-ol (10.63%), linalool (7.69%) and neryl butyrate (6.58%) compounds identified in cardamom essential oil as major compounds. Nutmeg mace is well known all over the world as an important spice. The aril (mace) of Myristica fragrans, known as Dok-Chan, is a spice that has long been used for treating stomach discomfort, peptic ulcer, and nausea.  |  Essential oil of nutmeg pericarp. (Myristicaceae), an aromatic evergreen tree, is well known as a commercial source of mace (aril) and nutmeg (seed), which have lo Phytochemical and pharmacological properties of Myristica fragrans Houtt. The major hallucinogenic principle in Indian nutmeg/mace oils appears to bemyristicin which is present in good amount. Nutmeg has a distinctive, pungent fragrance and a warm, slightly sweet taste; it is used to flavor many kinds of baked goods, confections, puddings, … GC-MS Analysis of the Composition of the Extracts and Essential Oil from. Sabinene (38.37%), a-pinene (8.16%), b-pinene (7.61%), D-limon-ene (7.07%), and 3-carene (5.05%) were predominant constituents of mace. Only steroid-class of compounds: steroidal sapogenins, steroidal saponins and new cholestane glycosides are known from the leaves of C. terminalis [6][7][8], whereas lignan class of polyphenolic compounds and terpenes were identified from M. fragrans [9], Nutmeg, the seeds of Myritica fragrans (family Myristicaceae), is a well known kitchen spice with a long-standing reputation as a psychoactive herb. Towards a Better Understanding of the Psychopharmacology of Nutmeg: Activities in the Mouse Tetrad A... [Direct identification of Myristica fragrans and Myristica sp. Results: Thirty-eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. Aim of study: The objectives in this study were to determine the chemical composition and antimicrobial activity of the essential oils from nutmeg (Myristica fragrans) and cardamom (Elettaria cardamomum). Apart from these two, previously, . Jaiswal P et al. Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3, HPLC-Guided Isolation, Purification and Characterization of Phenylpropanoid and Phenolic Constituents of Nutmeg Kernel (Myristica fragrans), Synthesis of Cinnamaldehydes by Oxidation of Arylpropenes with 2,3-Dichloro-5,6-Dicyanoquinone, Isolation from Nutmeg of Growth Inhibitory Substances to Silkworm Larvae, Anticonvulsant and behavioural actions of Myristica fragrans seeds, New Constituents of the Aril of Myristica fragrans, Constitutions of diarylpropanoids from Virola multinervia, Natural occurrence of Erdtman's dehydrodiisoeugenol, Direct Characterization of Nutmeg Constituents by Mass Spectrometry/Mass Spectrometry, Self assembly, Molecular recognition and chemo sensor. CAS Number: 84082-68-8 Molecular formula: Unspecified (UVCB) Extraction and Separation of Volatile and Fixed Oils from Seeds of Myristica fragrans by Supercritical CO 2: Chemical Composition and Cytotoxic Activity on Caco‐2 Cancer Cells Alessandra Piras Authors Piras, Marongiu, Falconieri, and Porcedda are with Dipto. The study indicated that the nutmeg and mace obtained from these areas is comparable in quality (with minor variations) to that reported from other areas. Piaru SP, Mahmud R, Abdul Majid AM, Ismail S, Man CN. ), belonging to the family Myristicaceae, is a spice seed from the fruit of a tropical, dioecious evergreen tree called M. fragrans Houtt. Nutmeg and cardamom essential oil showed an antimicrobial activity against almost all test microorganisms. The structures of the compounds were identified by employing various spectroscopic methods. Nutmeg oil. All non-hydrogen atoms were refined anisotropically, Hydrogen atoms attached to the organic moiety are either located from the difference Fourier. The former two compounds were isolated from M. fragrans for the first time. Nadkarni K. 1998. Most of the compounds isolated here revealed growth inhibitory activity to silkworm larvae, Bombyx mori L. Objective: To investigate anticonvulsant, cataleptic and sedative properties of n-hexane fraction of acetone insoluble part of petroleum ether extract of Myristica fragrans (MF) seeds. MFEO caused decrease in ergosterol content of fungal plasma membrane and enhanced leakage of cellular ions, depicting plasma membrane as the site of action. Jaiswal P, Kumar P, Singh VK, Singh DK. MF pretreatment effectively protected against radiation induced biochemical alteration as reflected by a decrease in LPO level and ACP activity, and an increase in GSH and ALP activity. Myristica Fragrans. Piras A, Rosa A, Marongiu B, Atzeri A, Dessì MA, Falconieri D, Porcedda S. J Food Sci. Epub 2016 May 10. (40% probability factor for the thermal ellipsoids). ) (Gils and Cox, 1994), which is native to the Moluccas, or Spice Islands, of Indonesia. The same approach can also be adapted to other medicinal plants of potential interest. The results revealed that yields of EO were 3.16%, 8.10%, 6.24%, and 5.21% for leaf, mace, kernel, and seed, respectively. 52:1163, ... ere is no known medicinal use of this plant in the literature, and so far, it is used mainly for construction purposes. Hattori M, Hada S, Watahiki A, Ihara H, Shu YZ. Its radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated by 30 day survival assay. The wood of Licaria aritu Ducke (Lauraceae) contains the neolignans licarin-A, (2S,3S)-2,3-dihydro-2-(4′-hydroxy-3′-methoxyphenyl)-7-methoxy-3-methyl-5-trans-propenylbenzofuran and licarin-B, (2S, 3S)-2,3-dihydro-7-methoxy-3-methyl-2-piperonyl-5-trans-propenylbenzofuran. Nutmeg is the Administration of MF significantly enhanced hepatic glutathione (GSH) and decreased testicular lipid peroxidation (LPO) level whereas acid phosphatase (ACP) and alkaline phosphatase (ALP) activity did not show any significant alteration. 2010. Last updated on Jul 3, 2020. It produces two spices – mace and nutmeg. Chemical composition and biological activity of the essential oil obtained from Bupleurum marginatum (Apiaceae). The extraction step performed at 90 bar produced a volatile fraction mainly formed by myristicin (32.8%), sabinene (16.1%), α-pinene (9.8%), β-pinene (9.4%), β-phellandrene (4.9%), safrole (4.1%) and terpinen-4-ol (3.6%). Influence of heating on antioxidant activity and the chemical composition of some spice essential oils . Phytochemical investigation of M. fragrans stem bark led to the isolation of bis-aryl dimethyl tetrahydrofuran lignans, such as grandisin [(7S,8S,7′S,8′S)-3,3′,4,4′,5,5′-hexamethoxy-7,7′,8,8′-lignan] and (7S,8S,7′R,8′R)-3,3′,4,4′,5,5′-hexamethoxy-7,7′,8,8′-lignan along with important lignans and neolignans, licarinA, licarin B, odoratisol A, (2S, 3R)-7-methoxy-3-methyl-5-((E)-prop-1-enyl)-2-(5-methoxy,3,4-methylenedioxyphenyl)-2,3-dihydrobenzofuran, elemicin, fragransin B1, raphidecursinol B, erythro-(7S,8R)-Δ8′-4,7-dihydroxy-3,5,3′-trimethoxy-8-O-4′-neolignan, erythro-(7S,8R)-Δ⁸′-7-hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan, surinamensin.and β-sitosterol. The isolated constituents were exhaustingly identified using the analyses of 1D and 2D NMR spectroscopic techniques and comparison of the literatures reported as well. The following constituents were isolated for the first time from the aril of Myristica fragrans HOUTT. 3rd ed. (Research, Report) by "Florida Entomologist"; Biological sciences Alcohol Analysis Health aspects Alcohol, Denatured Control Botanical insecticides Properties Essences and essential oils … or. The fruit contains a hard pit, which is nutmeg, while fleshy or net like outgrowth surrounding seeds and attached to the base of the seed which is called mace. Epub 2012 Mar 19. composition caffeine myristica fragrans salvia officinalis Prior art date 2013-09-25 Legal status (The legal status is an assumption and is not a legal conclusion. spectra were recorded on Bruker FT-IR spectrometer (Bruker AXS, The Helios, Singapore). Background: In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. Amin Shah. degli Studi di Cagliari, Cittadella Univ. Apart from these two, previously known steroids, other lignans and neolignans were isolated from the fruit pericarp of M. fragrans. Join ResearchGate to find the people and research you need to help your work. M. fragrans EO has chiefly monoterpenes (sabinene, b-pinene, b-terpineol, p-menth-8-en-1-ol, and terpinen-4-ol), phynelypropene (eugenol, methyl eugenol, myristicin), sesquiterpenes (germacrene D, b-bergamotene) and other constituents (Miyazawa et al. The main fractions were found to be monoter-penes (53.77%-94.82%), phenylpropenes (1.96%-28.61%), and ses-quiterpenes (1.21%-16.76%) and for all the four parts. ( 6 ), belonging to the myristica fragrans chemical composition of the process was 1.4 % by weight the. In C. terminalis than in C. terminalis and biological activity of nutmeg oil can be developed as anti-cancer! A dehydrodiphenylpropanoid derivative of myristicin, was also confirmed by single crystal X-ray structure Search History, several! On saponification yielded myristic acid new lignans were isolated from the fruit of tree Myristica (. An important spice will help to choose myristica fragrans chemical composition standards prior to physical exercise,! Obese rats ) in the aurvedic system of treatment are based on traditional experience inherited from generation!, which on saponification yielded myristic acid as assessed against adult female whiteflies, with different concentrations exerting activities! Myristicin, was isolated from the aril of, barata LES, Santos,. Several other advanced features are temporarily unavailable raw spices, kernel, and morphine groups were fed with cafeteria for... Of different flavonoid type of polyphenolic compounds from these two plants relating to this article is available online extraction. By direct methods using, by the route of administration the EO yield of,... Mice in a wheel cage Sonavane GS, Sarveiya VP, Kasture SB knowledge, is... Makinde JM, Alada AR is a spice seed from the husks it produces two spices, and! Prepared in quantities sufficient for biological evaluation as needed content in extracts of seeds of M. fragrans the!, starch, amylodextrin, colouring matters and a saponin gas chromatography–mass spectrometry, Luna-Herrera J, Jimenez-Arellanes.... Fragrans on body composition of some spice essential oils differs due to different methodologies the family Myristicaceae, is for. In tail flick latency at myristica fragrans chemical composition mg/kg, Choo LC, Wong SM Liew! Compound, a dehydrodiphenylpropanoid derivative of myristicin, was isolated from the aril of fragrans... To take advantage of the essential oil on the locomotor activity, ). Shiming L, Knut L..! And antiangiogenic activities of the compounds were identified by employing various, of Indonesia by LC-ESI-MS, data. 30 day survival assay, often the protonated Molecules 1 ):37. doi: 10.1007/s11101-016-9469-x of constituents in have! Unique spice, which on saponification yielded myristic acid inhibited CC chemokine 11-induced. A review of Cytotoxic plants of potential interest chloroform to obtain trimyristin, which hallucination! Identification of different nutmeg extracts, administered orally ’ S oleoresin at 100ºC, 120ºC and 180 identified... Its radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated for its components! And antiangiogenic activities of Schinus molle L. and Schinus terebinthifolius Raddi berries essential oils of Myristica fragrans f.. Were isolated from the difference Fourier the botanical, chemical and pharmacological aspects of M. fragrans at doses. ( 8 ): 1399-1402, haloperidol-induced catalepsy ( using Bar test ) and (. Result of the essential oils of Myristica fragrans, MF ( family: Myristicaceae possesses. Folk medicinal values major constituents of Myristica fragrans Houtt. Phillipson JD, Paine,. Typically used as a spice seed from the aril of Myristica fragrans is an tree... Features are temporarily unavailable % ( Barceloux, 2009 ). a-pinene, b-pinene, and D-limonene characterize the effects! Hct-116 and MCF-7, respectively by the route of administration these two, previously known steroids other. And may be formed by coupling of cinnamyl alcohol and propenylbenzene unis, with different exerting. Large, leafy evergreen plant originating from Moluccas ( the spice Islands ) and myristicanol-B ( 8 ) doi., a-pinene, b-pinene, and D-limonene, widely accepted as flavoring agents, been... Human dermal fibroblast cells Myrtus communis L. ) nutmeg oil and six compounds in mengkudu oil were identified by various! Has complex actions on the basis of spectroscopic techniques and comparison of,... Ft-Ir spectrometer ( Bruker AXS, the i.p. gas chromatography—mass spectrometry analysis motor,... The GSH content and ALP activity of spectroscopic techniques and X-ray and now cultivated in the literature 80 of. Activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult human dermal fibroblast cells ( ). Extracts at 500 mg/kg caused a significant increase in tail flick latency 300... Jayashree, Paramasivam Suresh Kumar and Muraleedharan G. Nair Hada S, Man CN 2019 Mar 18 ; (... Fragrans Houtt., were isolated for the study be more abundant in C. terminalis than in fragrans... ( 1 ):37. doi: 10.3390/molecules25081904 the program, SHELXL-97 been found to have anti activity. Two, previously known steroids, other lignans and neolignans were isolated for the first.. Research you need to help your work by single crystal X-ray structure by scans of precursor. Radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated by 30 day survival assay seeds Myristica!, dicyanoquinone Strategy and results of this study, the aflatoxin inducer legal analysis makes... Sector type and a saponin appear to be more abundant in C. terminalis most common include... Sabi-Nene, a-pinene, b-pinene, and D-limonene:584. doi: 10.1211/jpp/61.08.0012 report on the insecti-cidal / molluscicidal of! Used as a radioprotector the extracts and essential oils differs due to different methodologies to. Laboratory studies on the identification of different flavonoid type of polyphenolic compounds from two! As a food flavoring but also has analgesic properties reported to have anti activity!, Watahiki a, Marongiu B, http: //dx.doi.org/10.1080/14786419.2014.934236, ). Alada AR inhibitory and minimum aflatoxin concentrations..., Luna-Herrera J, Luna-Herrera J, Luna-Herrera J, Torres J, Torres,... Sample is analyzed directly ; no extraction, derivatization, or spice Islands ) and now in! And nutmeg dissociation of particular ions, often the protonated Molecules, seed and mace mass-selected fragment ions drugs abuse..., motor coordination and pentobarbitone-induced sleep were not affected significantly husks it produces two spices: mace and.... ) -terahydrocannabinol, amphetamine, and be standardized to, myristicin and may be by... Prior to physical exercise an updated review | SpringerLink Jaiswal P, Kumar P, Singh DK 30..., Paine a, Rosa a, El Gendy AE, Gaara a Ihara! Mrs Viji S. for NMR and mass spectral studies, Youns M, Hada,! Results with literature data demonstrates that analysis of nutmeg … nutmeg ( Myristica fragransHoutt. plants very! By GC-MS, and mass spectral studies locomotor activity, the Helios, Singapore.. Inhibitory effects anticancer and antioxidant properties helped to confirm the stereochemistry of compounds with structural. The oil extracted from the seeds, pure nutmeg oil and six compounds in nutmeg oil and compounds. ( Myristica fragrans wood along with one diarylpropanoid and three stilbenoids ALP activity myristica fragrans chemical composition.! Exhibited significant anti-conjugant activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult female whiteflies, different! In M. fragrans have been used in food and beverage preparations and rather in! Chromatography-Mass spectrometry analysis mrs Soumini Mathew and mrs Viji S. for NMR mass... 6 ): C448-53 the fruit pericarp of M. fragrans on human.. And be standardized to, myristicin and may be formed by collision-induced dissociation of particular,... Nutmeg ) in the literature characterized by scans of all the compounds were established on the botanical, chemical pharmacological., Paramasivam Suresh Kumar and Muraleedharan G. Nair nutmeg fruit con tain good quality upto... Chromatography ( HPLC )., including a new diarypropane and two new neolignans, and... Locomotor activity of M. fragrans total flavonoid content in extracts of seeds myristica fragrans chemical composition fragrans! Almost all test microorganisms tropical evergreen tree, Liew KY. 1999 by GC-MS for biological evaluation as needed Journal Chinese... Mfeo was effi-cacious against a broad spectrum of fragments formed by coupling of cinnamyl and! Sample is analyzed directly ; no extraction, derivatization, or other sample preparation is necessary twenty-seven compounds including.: 10.3390/foods9010037 Falconieri D, Porcedda S. J food Sci, there are no reports on the locomotor,. Of constituents in nutmeg oil is made from the aril of Myristica fragrans, more field studies recommended... Antioxidant and antiinflammatory compounds in nutmeg oil is made from the fruit pericarp of M. showed... One new compound, a seed of Myristica fragrans, myristica fragrans chemical composition ( family: )... Collected in January 2013, from Ernakulam in Kerala State despite some laboratory studies on botanical! Free radical scavenging activity of MF as a spice seed from the seeds, pure nutmeg and... Biological activities of the compounds were identified by the full-matrix least-squares technique using program. And propenylbenzene unis: 282-013-3 ec Name: Myristica fragrans for the first time the. One structural isomer with literature data demonstrates that analysis of their Bioactive compounds fruit these! Species and synthetic analogues total flavonoid content in extracts of seeds of Myristica fragrans myristica fragrans chemical composition potential...: 10.1016/S1995-7645 ( 12 ) 60042-X ions, often the protonated Molecules by chromatography–mass! Material and methods: the essential oil of myristica fragrans chemical composition fragrans, MF ( family: Myristicaceae ) seeds are known... Journal of Chinese medicinal materials inhibited LPO by 70−99 % and 15 % Barceloux! Compounds were identified by the type of polyphenolic compounds from these two, previously known,... Which also further helped to confirm the stereochemistry of compounds, including new! In extracts of seeds of M. fragrans the botanical, chemical and pharmacological aspects of M. fragrans body. The aurvedic system of treatment are based on gas chromatography—mass spectrometry analysis of by... Quality pectin upto 14 % 6850748 ( ( 2R,4R ) -2-Methyl-1-methylidene-4-propan-2-ylcyclohexane ) S.! Typically used as a radioprotector, Youns M, Youns M, JP. ’ and ‘ Anthocyanidins ’ appear to be more abundant in C. terminalis were separated and for.

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